Starting YUVIWEL® (navepegritide)

StartingYUVIWEL®(navepegritide)

Porter, 4 years old

Taking YUVIWEL as part of a clinical trial since age 2

What to know before you start

1x weekly icon
YUVIWEL is a once-weekly injection. It can be given at any time of day that fits your family routine best. There’s no need to plan around meals, snacks, or bedtimes.
YUVIWEL 313 injection free days icon
Once weekly means 313 injection-free days per year, so you and your child can focus on the growing up that matters most.
YUVIWEL injection 2 days icon
While it’s best for YUVIWEL to be given on the same day each week, sometimes life happens and plans change. So, it’s good to know that the dosing day can be adjusted to 2 days before or 2 days after the planned dosing day if needed. Resume once-weekly dosing for the next dose at the usual dosing day.
Missed doses:
  • If more than 2 days have passed from the scheduled dosing day, skip the missed dose and give YUVIWEL on the next regularly scheduled day
  • There should be at least 5 days between doses
switch icon
Switch without missing a treatment day: Your child can start once-weekly YUVIWEL the day after their last dose of their daily CNP treatment.
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YUVIWEL is easy to store. Unmixed YUVIWEL can be kept in the fridge or at room temperature.
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Ascendis supports you with free at-home injection training, so you can learn how to give YUVIWEL to your child safely and properly.
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Once-weekly dosing reduces space, storage, and supplies needed for injections. Each carton of YUVIWEL contains 4 small kits with everything you need for 4 weekly injections.
ASAP icon
With A·S·A·P, you are never far from support. Your Patient Access Liaison (PAL) is someone you can reach out to for questions, information, and help along the way. Connect now

Giving YUVIWEL

YUVIWEL must be carefully mixed and prepared before administering. You will be trained by a healthcare professional on how to give YUVIWEL to your child. This Instructions for Use video can help you better understand the process.

For step-by-step instructions, you can also download a PDF in English or Español.
Tips for giving YUVIWEL
YUVIWEL should be injected in the abdomen (stomach, 2 inches from the belly button) or thighs. If given by a caregiver, injection in the buttocks or back of arms is also okay.
  • Wash hands before preparing YUVIWEL
  • Do not inject in skin that is red, swollen, or scarred
  • Rotate injection sites every week
    • If the treatment is split between 2 injections, choose 2 different sites
  • Keep track of sites from week to week to make sure you are rotating properly
  • Read the Instructions for Use that come with your child’s YUVIWEL for information on how to store, prepare, and give YUVIWEL, as well as how to dispose of YUVIWEL the right way

Where to inject YUVIWEL

YUVIWEL where to inject map image YUVIWEL where to inject map image

Treatment guidance and storage

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The YUVIWEL dose is based on weight. Your healthcare team will keep track of how much your child weighs and adjust their dose as needed.
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Store unmixed YUVIWEL in a refrigerator. YUVIWEL can also be stored at room temperature (up to 86 °F) for up to 6 months. YUVIWEL does not contain preservatives.

After mixing, YUVIWEL can be stored at room temperature and must be used within 4 hours. Throw away unused medicine.
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Get a text when it’s time to give YUVIWEL

The A·S·A·P Text Messaging Service is designed to help you and your child stay on track with injections when taking YUVIWEL.

Sign up now

Connect with a PAL and register for updates

A Patient Access Liaison (PAL) can provide you with individualized support and education about achondroplasia and treatment with YUVIWEL. Fill out the form below to receive important information about YUVIWEL and connect with a PAL.

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What is YUVIWEL?
YUVIWEL is a prescription medicine used to increase linear growth in children 2 years and older with achondroplasia with open growth plates (epiphyses).

YUVIWEL is approved under accelerated approval based on an improvement in annualized growth velocity. Continued approval may be contingent upon verification and description of clinical benefit in confirmatory trials.

USE AND IMPORTANT SAFETY INFORMATION

IMPORTANT SAFETY INFORMATION

What are the possible side effects of YUVIWEL?
YUVIWEL may cause serious side effects, including risk of low blood pressure. If your child experiences a decrease in blood pressure or symptoms of low blood pressure (dizziness, feeling tired, and/or nausea) while being treated with YUVIWEL, call your child’s healthcare provider.

The most common side effects of YUVIWEL include injection site

What is YUVIWEL?
YUVIWEL is a prescription medicine used to increase linear growth in children 2 years and older with achondroplasia with open growth plates (epiphyses).

YUVIWEL is approved under accelerated approval based on an improvement in annualized growth velocity. Continued approval may be contingent upon verification and description of clinical benefit in confirmatory trials.

USE AND IMPORTANT SAFETY INFORMATION

What is YUVIWEL?
YUVIWEL is a prescription medicine used to increase linear growth in children 2 years and older with achondroplasia with open growth plates (epiphyses).

YUVIWEL is approved under accelerated approval based on an improvement in annualized growth velocity. Continued approval may be contingent upon verification and description of clinical benefit in confirmatory trials.

IMPORTANT SAFETY INFORMATION

What are the possible side effects of YUVIWEL?

YUVIWEL may cause serious side effects, including risk of low blood pressure. If your child experiences a decrease in blood pressure or symptoms of low blood pressure (dizziness, feeling tired, and/or nausea) while being treated with YUVIWEL, call your child’s healthcare provider.

The most common side effects of YUVIWEL include injection site reactions (redness, itching, skin discoloration, bleeding, swelling, bruising, pain, and blistering).

Before you give YUVIWEL to your child, tell the healthcare provider about all of your child’s medical conditions, including if they:

  • have kidney problems
  • are pregnant or plan to become pregnant. It is not known if YUVIWEL will harm the unborn baby
  • are breastfeeding or plan to breastfeed. It is not known if YUVIWEL passes into breast milk

Tell the healthcare provider about all the medicines your child takes, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

These are not all of the possible side effects of YUVIWEL. Call your doctor for medical advice about side effects. You are encouraged to report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch. You may also report side effects to Ascendis Pharma at 1-844-442-7236.

Please see the full Prescribing Information and Patient Information for YUVIWEL.

CNP=C-type natriuretic peptide.